Rapid Communications in Mass Spectrometry : RCM via MedWorm.com

1. Dissection of the antitumor mechanism of tetrandrine based on metabolite profiling and network pharmacology
   CONCLUSIONS: The metabolism features of tetrandrine and its potential antitumor mechanism were summarized, providing data for further pharmacological validation.PMID:38073199 | DOI:10.1002/rcm.9662 (Source: Rapid Communications in Mass Spectrometry : RCM)
2. Spectral libraries from nucleobases and deoxyribonucleosides facilitate the identification of ribonucleosides by nano-flow liquid chromatography-tandem mass spectrometry
   CONCLUSIONS: The study demonstrates the efficacy of utilizing homologous nucleobases and deoxyribonucleosides as interchangeable reference spectral libraries for identifying modified ribonucleosides and their positional isomers. This approach offers a valuable solution for overcoming limitations posed by the unavailability of commercial standards, enhancing the analysis of RNA post-transcriptional modifications via mass spectrometry.PMID:38680121 | DOI:10.1002/rcm.9759 (Source: Rapid Communications in Mass Spectrometry : RCM)
3. Differentiation of isobaric cross-linked peptides prepared via maleimide chemistry using MALDI-MS and MS/MS
   CONCLUSIONS: The thiosuccinimide (but not thiazine) form of the cross-linked peptide yielded individual constituent peptides using MALDI-MS and MALDI-MS/MS, showing specific 1,4-elimination for the thiosuccinimide form and cleavage at the newly formed peptide bond via transcyclization for the thiazine form.PMID:38124166 | DOI:10.1002/rcm.9660 (Source: Rapid Communications in Mass Spectrometry : RCM)
4. Rapid discrimination of geographical origin of garlic (Allium sativum L.): A metabolomic approach applied to paper spray mass spectrometry data
   CONCLUSION: Hence, this combined strategy holds promise not only as an effective tool for the authentication of the geographical origin of garlic but also as a powerful means for biomarker discovery.PMID:38682308 | DOI:10.1002/rcm.9743 (Source: Rapid Communications in Mass Spectrometry : RCM)
5. Clumped isotope analysis of (bio)apatite using a Kiel IV device in long-integration dual-inlet mode
   CONCLUSIONS: (Bio)apatites having low organic matter content such as enamel(oid) can be analyzed accurately for Δ47 using a Kiel IV equipped with water sinks that ensure effective removal of water. Secondary calcite can be effectively removed from carbonate-bearing apatite by pretreatment with 1 M acetic acid (pH = 5) for 1 h.PMID:37953541 | DOI:10.1002/rcm.9656 (Source: Rapid Communications in Mass Spectrometry : RCM)
6. Rapid analysis of the chemical constituents of traditional Tibetan medicine Sbyor-bzo-ghi-wang using ballpoint electrospray ionization technique
   CONCLUSIONS: Compared with the traditional HPLC-MS/MS methods, the BPESI technique does not require complex sample pretreatment and subsequent chromatographic separation steps; also it consumes a small quantity of samples. Therefore, BPESI can be used for the qualitative analysis of the chemical constituents of Sbyor-bzo-ghi-wang.PMID:38682312 | DOI:10.1002/rcm.9760 (Source: Rapid Communications in Mass Spectrometry : RCM)
7. Development of in situ Li isotope analysis using laser ablation quadrupole inductively coupled plasma mass spectrometry
   CONCLUSION: Lithium isotope analysis by ns-LA-QICPMS is worthwhile for samples with high Li concentrations and when a matrix-matched standard can be obtained. Although the precision of this method is not as high as those achievable with SIMS and LA-MC-ICPMS, it remains adequate for resolving large isotope fractionations found in natural and laboratory settings.PMID:38124171 | DOI:10.1002/rcm.9668 (Source: Rapid Communications in Mass Spectrometry : RCM)
8. Quality evaluation of natural monomer flavors for Chinese tobacco industry based on dual mode combined Fourier transform ion cyclotron resonance mass spectrometry and isotopic fine structures
   CONCLUSIONS: The integration strategy established here can discover and quantify the chemical markers for improving the quality control standard of natural monomer flavor of licorice. It is expected that the strategy will be valuable for further quality control of other natural monomer flavors in Chinese tobacco industry.PMID:38644558 | DOI:10.1002/rcm.9748 (Source: Rapid Communications in Mass Spectrometry : RCM)
9. Dissection of the antitumor mechanism of tetrandrine based on metabolite profiling and network pharmacology
   CONCLUSIONS: The metabolism features of tetrandrine and its potential antitumor mechanism were summarized, providing data for further pharmacological validation.PMID:38073199 | DOI:10.1002/rcm.9662 (Source: Rapid Communications in Mass Spectrometry : RCM)
10. The effects of modifiers on electrospray ionization for small-to-medium-sized molecules in comparison with solution-phase ionization
    Rapid Commun Mass Spectrom. 2024 Jul 15;38(13):e9749. doi: 10.1002/rcm.9749.ABSTRACTModifiers are essential additives in electrospray ionization (ESI) mass spectrometric analysis to enhance the production of ionic species in the gas phase for the detection of small-to-medium-sized molecules in biological and aqueous samples. Therefore, an appropriate modifier, in conjunction with the right ionization polarity, is crucial for sensitive ESI mass spectrometric analysis. However, the charge carried by basic and acidic functional groups in solution is neither quantitatively nor qualitatively reflected in the MS spectrum. For example, adding an acidic modifier will cause sufficient protonation of a basic functional group in solution; however, this may result in inferior positive ESI compared to ...
11. Using sulfur stable isotope ratios ( δ < sup > 34 < /sup > S) for animal geolocation: Estimating the delay mechanisms between diet ingestion and isotope incorporation in tail hair
    CONCLUSION: Our findings help to unravel the underlying complexities associated with sulfur metabolism and are broadly consistent with results from other species. These findings will help to inform research aiming to apply the variation of δ34 S in inert biological material for geolocation or understanding dietary changes, especially for fast moving migratory ungulates such as wildebeest.PMID:38124168 | DOI:10.1002/rcm.9674 (Source: Rapid Communications in Mass Spectrometry : RCM)
12. Installation protocol for charge transfer dissociation mass spectrometry on ion trapping mass spectrometers
    CONCLUSIONS: Here, we provide a visual protocol to help others accomplish the instrument modification.PMID:38616287 | DOI:10.1002/rcm.9750 (Source: Rapid Communications in Mass Spectrometry : RCM)
13. Liquid chromatography-mass spectrometry-based metabolomics and fluxomics reveals the metabolic alterations in glioma U87MG multicellular tumor spheroids versus two-dimensional cell cultures
    CONCLUSIONS: Our study highlights specific, altered biochemical pathways in MCTSs, emphasizing dysregulation of energy metabolism and lipid metabolism, and offering novel insight into metabolic events in glioma MCTSs.PMID:38124173 | DOI:10.1002/rcm.9670 (Source: Rapid Communications in Mass Spectrometry : RCM)
14. Solvent-free sample preparation for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of polymer blends
    CONCLUSIONS: The results clearly show that solvent-free sample preparation must be carefully considered when applied to synthetic polymer blends, as it may cause additional problems with regard to homogeneity and stability of the blends.PMID:38616296 | DOI:10.1002/rcm.9756 (Source: Rapid Communications in Mass Spectrometry : RCM)
15. Identifying the active compounds and mechanism of action of TongFu XieXia Decoction for treating intestinal obstruction using network pharmacology combined with ultra-high performance liquid chromatography-quadrupole-orbitrap mass spectrometry
    CONCLUSION: Molecular docking studies substantiated the substantial affinity between the TFXXD bioactive constituents and their corresponding targets in the context of IO. TFXXD exerts its therapeutic efficacy in IO through a multifaceted interplay between multiple compounds, targets, and pathways. The integration of network pharmacology with UPLC-Q-Orbitrap-MS/MS has emerged as a promising strategy to unravel the intricate web of molecular interactions underlying herbal medicine. However, it is imperative to emphasize the necessity for further in vivo and in vitro experiments.PMID:38124169 | DOI:10.1002/rcm.9664 (Source: Rapid Communications in Mass Spectrometry : RCM)